Cranial irradiation disrupts homeostatic microglial dynamic behavior.

ABSTRACT: Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in shape and morphology depending on the function they are performing. Additionally, microglia processes make dynamic, physical contacts with different components of their environment to monitor the functional state of the brain and promote plasticity. Though evidence suggests radiation perturbs homeostatic microglia functions, it is unknown how cranial irradiation impacts the dynamic behavior of microglia over time. Here, we paired in vivo two-photon microscopy with a transgenic mouse model that labels cortical microglia to follow these cells and determine how they change over time in cranial irradiated mice and the

SUBMITTER: Strohm AO 

PROVIDER: S-EPMC10993621 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature