Determinants and impact of calcium oxalate crystal deposition on renal outcomes in acute kidney injury patients.

ABSTRACT:

Objectives

Calcium oxalate (CaOx) crystal deposition in acute kidney injury (AKI) patients is under recognized but impacts renal outcomes. This study investigates its determinants and effects.

Methods

We studied 814 AKI patients with native kidney biopsies from 2011 to 2020, identifying CaOx crystal deposition severity (mild: <5, moderate: 5-10, severe: >10 crystals per section). We assessed factors like urinary oxalate, citrate, urate, electrolytes, pH, tubular calcification index, and SLC26A6 expression, comparing them with creatinine-matched AKI controls without oxalosis. We analyzed how these factors relate to CaOx severity and their impact on renal recovery (eGFR < 15 mL/min/1.73 m² at 3-month follow-up).

Results

CaOx crystal deposition was found in 3.

SUBMITTER: Yang W 

PROVIDER: S-EPMC10993744 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature