Testing pulmonary physiology in ventilated non-human primates.

ABSTRACT:

Background

Animal models of respiratory viral infections are essential for investigating disease pathogenesis and the efficacy of antivirals and vaccine candidates. A major limitation in the research of respiratory diseases in animal models is correlating clinically relevant changes in pulmonary physiology with cellular and molecular mechanistic studies. Few animal models have captured and correlated physiologic changes in lung function and immune response within same experiment, which is critical given the heterogeneous nature of lung disease due to viral infections. In ventilated human patients, pulmonary physiology testing can be used to not only capture oxygenation, ventilation, but also pulmonary mechanics to yield quantitative measures of lung function and scalar tracings of

SUBMITTER: Cervantes O 

PROVIDER: S-EPMC10994148 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature