Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.

ABSTRACT: Immunotherapies for malignant melanoma seek to boost the anti-tumoral response of CD8⁺ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration. Genetic or pharmacological inhibition of the pannexin 1 (PANX1) channel-forming protein is known to decrease melanoma cell tumorigenic properties in vitro and ex vivo. Here, we crossed Panx1 knockout (Panx1^-/-) mice with the inducible melanoma model Braf^CA, Pten^loxP, Tyr::CreER^T2 (BPC). We found that deleting the Panx1 gene in mice does not reduce BRAF(V600E)/Pten-driven primary tumor formation or improve survival. However, tumors in BPC-Panx1^-/- mice exhibited a significant increase in the infiltration of CD8⁺ T lymphocyt

SUBMITTER: Sanchez-Pupo RE 

PROVIDER: S-EPMC10994229 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature