Systematic analysis of cuproptosis abnormalities and functional significance in cancer.

ABSTRACT:

Background

Cuproptosis is a recently discovered type of cell death, but the role and behavior of cuproptosis-related genes (CuRGs) in cancers remain unclear. This paper aims to address these issues by analyzing the multi-omics characteristics of cancer-related genes (CuRGs) across various types of cancer.

Method

To investigate the impact of somatic copy number alterations (SCNA) and DNA methylation on CRG expression, we will analyze the correlation between these factors. We developed a cuproptosis index (CPI) model to measure the level of cuproptosis and investigate its functional roles. Using this model, we assessed the clinical prognosis of colorectal cancer patients and analyzed genetic changes and immune infiltration features in different CPI levels.

Results

The s

SUBMITTER: Rumin S 

PROVIDER: S-EPMC10994309 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature