The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity.

ABSTRACT: Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction in schizophrenia. The inhibitory deficit results from additional noise during information processing in the motor system in psychosis. Here, we tested whether cortical inhibitory dysfunction was linked to psychomotor slowing and motor network alterations. In this cross-sectional study, we included 60 patients with schizophrenia and psychomotor slowing determined by the Salpêtrière Retardation Rating Scale, 23 patients without slowing and 40 healthy control participants. We acquired single and double-pulse transcranial magnetic stimulation effects from the left primary motor cortex, resting-state functional conn

SUBMITTER: Lefebvre S 

PROVIDER: S-EPMC10994557 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature