Phenotypic screening reveals a highly selective phthalimide-based compound with antileishmanial activity.

ABSTRACT: Pharmacophores such as hydroxyethylamine (HEA) and phthalimide (PHT) have been identified as potential synthons for the development of compounds against various parasitic infections. In order to further advance our progress, we conducted an experiment utilising a collection of PHT and HEA derivatives through phenotypic screening against a diverse set of protist parasites. This approach led to the identification of a number of compounds that exhibited significant effects on the survival of Entamoeba histolytica, Trypanosoma brucei, and multiple life-cycle stages of Leishmania spp. The Leishmania hits were pursued due to the pressing necessity to expand our repertoire of reliable, cost-effective, and efficient medications for the treatment of leishmaniases. Antileishmanials must possess the

SUBMITTER: Zahedifard F 

PROVIDER: S-EPMC10994559 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature