Efficacy of Levetiracetam as Add-On Therapy in the Treatment of Seizures in Neonates.

ABSTRACT:

Introduction

There is no consensus regarding the efficacy of add-on therapy with levetiracetam (LEV) in the treatment of seizures in neonates. The aim of this study was to evaluate the efficacy of add-on therapy with LEV for achieving >80% seizure reduction after phenobarbital (PB) treatment.

Methods

Retrospective cohort study of near term neonates admitted to the neonatal intensive care unit with EEG-confirmed seizures despite treatment with PB as first-line therapy and using LEV as 2nd-, 3rd- or 4th-line treatment. Antiseizure medication was administered according to national guidelines. All neonates were monitored with 2-channel amplitude-integrated electroencephalography. The total seizure burden in minutes, 2 h before and 4 h after administration of LEV, was calculat

SUBMITTER: Rondagh M 

PROVIDER: S-EPMC10994567 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature