CLAUDIO: automated structural analysis of cross-linking data.

ABSTRACT:

Motivation

Cross-linking mass spectrometry has made remarkable advancements in the high-throughput characterization of protein structures and interactions. The resulting pairs of cross-linked peptides typically require geometric assessment and validation, given the availability of their corresponding structures.

Results

CLAUDIO (Cross-linking Analysis Using Distances and Overlaps) is an open-source software tool designed for the automated analysis and validation of different varieties of large-scale cross-linking experiments. Many of the otherwise manual processes for structural validation (i.e. structure retrieval and mapping) are performed fully automatically to simplify and accelerate the data interpretation process. In addition, CLAUDIO has the ability to remap intra-pro

SUBMITTER: Rohl A 

PROVIDER: S-EPMC10994719 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature