Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue.

ABSTRACT: Many cell types require direct cell-cell interactions for differentiation and function; yet, this can be challenging to incorporate into 3-dimensional (3D) structures for the engineering of tissues. Here, a new approach is introduced that combines aggregates of cells (spheroids) with similarly-sized hydrogel particles (microgels) to form granular composites that are injectable, undergo interparticle crosslinking via light for initial stabilization, permit cell-cell contacts for cell signaling, and allow spheroid fusion and growth. One area where this is important is in cartilage tissue engineering, as cell-cell contacts are crucial to chondrogenesis and are missing in many tissue engineering approaches. To address this, granular composites are developed from adult porcine mesenchymal strom

SUBMITTER: Caprio ND 

PROVIDER: S-EPMC10994732 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature