Differential effects of translation inhibitors on Plasmodium berghei liver stage parasites.

ABSTRACT: Increasing numbers of antimalarial compounds are being identified that converge mechanistically at inhibition of cytoplasmic translation, regardless of the molecular target or mechanism. A deeper understanding of how their effectiveness as liver stage translation inhibitors relates to their chemoprotective potential could prove useful. Here, we probed that relationship using the Plasmodium berghei-HepG2 liver stage infection model. After determining translation inhibition EC₅₀s for five compounds, we tested them at equivalent effective concentrations to compare the parasite response to, and recovery from, a brief period of translation inhibition in early schizogony, followed by parasites to 120 h post-infection to assess antiplasmodial effects of the treatment. We show co

SUBMITTER: McLellan JL 

PROVIDER: S-EPMC10994859 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature