Neuron enriched extracellular vesicles' MicroRNA expression profiles as a marker of early life alcohol consumption.

ABSTRACT: Alcohol consumption may impact and shape brain development through perturbed biological pathways and impaired molecular functions. We investigated the relationship between alcohol consumption rates and neuron-enriched extracellular vesicles' (EVs') microRNA (miRNA) expression to better understand the impact of alcohol use on early life brain biology. Neuron-enriched EVs' miRNA expression was measured from plasma samples collected from young people using a commercially available microarray platform while alcohol consumption was measured using the Alcohol Use Disorders Identification Test. Linear regression and network analyses were used to identify significantly differentially expressed miRNAs and to characterize the implicated biological pathways, respectively. Compared to alcohol naïve co

SUBMITTER: Yakovlev V 

PROVIDER: S-EPMC10994930 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature