Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults.

ABSTRACT:

Background

Identifying individuals before the onset of overt symptoms is key in the prevention of Alzheimer's disease (AD).

Objectives

Investigate the use of miRNA as early blood-biomarker of cognitive decline in older adults.

Design

Cross-sectional.

Setting

Two observational cohorts (CHARIOT-PRO, Alzheimer's Disease Neuroimaging Initiative (ADNI)).

Participants

830 individuals without overt clinical symptoms from CHARIOT-PRO and 812 individuals from ADNI.

Measurements

qPCR analysis of a prioritised set of 38 miRNAs in the blood of individuals from CHARIOT-PRO, followed by a brain-specific functional enrichment analysis for the significant miRNAs. In ADNI, genetic association analysis for polymorphisms within the significant miRNAs' genes and CSF

SUBMITTER: Sadlon A 

PROVIDER: S-EPMC10994991 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature