Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response.

ABSTRACT:

Background

Since the beginning of the anti-COVID-19 vaccination campaign, it has become evident that vaccinated subjects exhibit considerable inter-individual variability in the response to the vaccine that could be partly explained by host genetic factors. A recent study reported that the immune response elicited by the Oxford-AstraZeneca vaccine in individuals from the United Kingdom was influenced by a specific allele of the human leukocyte antigen gene HLA-DQB1.

Methods

We carried out a genome-wide association study to investigate the genetic determinants of the antibody response to the Pfizer-BioNTech vaccine in an Italian cohort of 1351 subjects recruited in three centers. Linear regressions between normalized antibody levels and genotypes of more than 7 million varian

SUBMITTER: Esposito M 

PROVIDER: S-EPMC10995155 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature