Soluble individual metal atoms and ultrasmall clusters catalyze key synthetic steps of a natural product synthesis.

ABSTRACT: Metal individual atoms and few-atom clusters show extraordinary catalytic properties for a variety of organic reactions, however, their implementation in total synthesis of complex organic molecules is still to be determined. Here we show a 11-step linear synthesis of the natural product (±)-Licarin B, where individual Pd atoms (Pd₁) catalyze the direct aerobic oxidation of an alcohol to the carboxylic acid (steps 1 and 6), Cu_2-7 clusters catalyze carbon-oxygen cross couplings (steps 3 and 8), Pd_3-4 clusters catalyze a Sonogashira coupling (step 4) and Pt_3-5 clusters catalyze a Markovnikov hydrosylilation of alkynes (step 5), as key reactions during the synthetic route. In addition, the new synthesis of Licarin B showcases an unexpected selective

SUBMITTER: Rodriguez-Nuevalos S 

PROVIDER: S-EPMC10995175 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature