Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.

ABSTRACT: Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic prevention of cancer metastasis. It remains elusive how CTCs evade immune surveillance and elimination by immune cells. In this study, we unequivocally identified a subpopulation of CTCs shielded with extracellular vesicle (EVs)-derived CD45 (termed as CD45⁺ CTCs) that resisted T cell attack. A higher percentage of CD45⁺ CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer patients. Moreover, CD45⁺ tumor cells orchestrated an immunosuppressive milieu and CD45

SUBMITTER: Yang C 

PROVIDER: S-EPMC10995208 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature