Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING-HF trial.

ABSTRACT:

Background

Iron deficiency (ID) is associated with impaired functional capacity in patients with heart failure (HF), even in those with preserved ejection fraction (HFpEF). This study aimed to evaluate the effect of baseline ferrokinetics on peak oxygen consumption (peakVO₂) improvement after a 12-week physical therapy programme in patients with stable HFpEF.

Methods

This study is a post-hoc sub-analysis of a randomized clinical trial in which 59 stable patients with HFpEF were randomized to receive a 12-week programme of inspiratory muscle training (IMT), functional electrical stimulation (FES), IMT + FES or usual care (UC) to evaluate change in peakVO₂ (NCT02638961). Serum ferritin and transferrin saturation (TSAT) determinations were assessed at base

SUBMITTER: Palau P 

PROVIDER: S-EPMC10995251 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature