Plasma microRNA signature associated with skeletal muscle wasting in post-menopausal osteoporotic women.

ABSTRACT:

Background

Skeletal muscle mass wasting almost invariably accompanies bone loss in elderly, and the coexistence of these two conditions depends on the tight endocrine crosstalk existing between the two organs, other than the biomechanical coupling. Since the current diagnostics limitation in this field, and given the progressive population aging, more effective tools are needed. The aim of this study was to identify circulating microRNAs (miRNAs) as potential biomarkers for muscle mass wasting in post-menopausal osteoporotic women.

Methods

One hundred seventy-nine miRNAs were assayed by quantitative real-time polymerase chain reaction in plasma samples from 28 otherwise healthy post-menopausal osteoporotic women (73.4 ± 6.6 years old). The cohort was divided in tertiles base

SUBMITTER: Faraldi M 

PROVIDER: S-EPMC10995257 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature