Chronic hypoxia impairs skeletal muscle repair via HIF-2α stabilization.

ABSTRACT:

Background

Chronic hypoxia and skeletal muscle atrophy commonly coexist in patients with COPD and CHF, yet the underlying physio-pathological mechanisms remain elusive. Muscle regeneration, driven by muscle stem cells (MuSCs), holds therapeutic potential for mitigating muscle atrophy. This study endeavours to investigate the influence of chronic hypoxia on muscle regeneration, unravel key molecular mechanisms, and explore potential therapeutic interventions.

Methods

Experimental mice were exposed to prolonged normobaric hypoxic air (15% pO₂, 1 atm, 2 weeks) to establish a chronic hypoxia model. The impact of chronic hypoxia on body composition, muscle mass, muscle strength, and the expression levels of hypoxia-inducible factors HIF-1α and HIF-2α in MuSC was examin

SUBMITTER: Yin A 

PROVIDER: S-EPMC10995261 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature