Prognostic value of initial and longitudinal changes in body composition in metastatic pancreatic cancer.

ABSTRACT:

Background

Sarcopenia or visceral adipose tissue has been reported to be related to pancreatic cancer prognosis. However, clinical relevance of the comprehensive analysis of body compositions and their longitudinal changes is lacking. This study analysed the association between body composition changes after chemotherapy and survival in patients with metastatic pancreatic cancer.

Methods

We retrospectively included 456 patients (mean age ± standard deviation, 61.2 ± 10.0 years; 272 males and 184 females) with metastatic pancreatic cancer who received palliative chemotherapy from May 2011 to December 2019. Using deep learning-based, fully automated segmentation of contrast-enhanced computed tomography (CT) at the time of diagnosis, cross-sectional areas of muscle, subcutaneou

SUBMITTER: Lee MW 

PROVIDER: S-EPMC10995276 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature