Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.

ABSTRACT:

Background

Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same individuals. Moreover, the impact of short-term exercise-supplemented remobilization (ESR) on muscle volume, protein turnover and leg glucose uptake (LGU) in humans is unknown.

Methods

Ten healthy males (24 ± 1 years, body mass index 22.7 ± 0.6 kg/m²) underwent 3 days of BR, followed immediately by 3 days of ESR consisting of 5 × 30 maximal voluntary single-leg isokinetic knee extensions at 90°/s each day. An isoenergetic diet was maintained throughout the study (30% fat, 15% protein and 55% carbohydrate). Resting LGU was

SUBMITTER: Shur NF 

PROVIDER: S-EPMC10995277 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature