Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis.

ABSTRACT:

Objective

To investigate the serum biomarkers in patients with drug-resistant epilepsy (DRE).

Methods

A total of 9 DRE patients and 9 controls were enrolled. Serum from DRE patients was prospectively collected and analyzed for potential serum biomarkers using TMT18-labeled proteomics. After fine quality control, bioinformatics analysis was conducted to find differentially expressed proteins. Pathway enrichment analysis identified some biological features shared by differential proteins. Protein-protein interaction (PPI) network analysis was further performed to discover the core proteins.

Results

A total of 117 serum differential proteins were found in our study, of which 44 were revised upwards and 73 downwards. The up-regulated proteins mainly include UGGT2, PDIA4,

SUBMITTER: Ma M 

PROVIDER: S-EPMC10995353 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature