Causal relationship between gut microbiota and rosacea: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Rosacea, a chronic inflammatory skin condition affecting millions worldwide, is influenced by complex interactions between genetic and environmental factors. Although gut microbiota's role in skin health is well-acknowledged, definitive causal links between gut microbiota and rosacea remain under-explored.

Methods

Using a two-sample Mendelian randomization (MR) design, this study examined potential causal relationships between gut microbiota and rosacea. Data was sourced from the largest Genome-Wide Association Study (GWAS) for gut microbiota and the FinnGen biobank for rosacea. A total of 2078 single nucleotide polymorphisms (SNPs) associated with gut microbiota were identified and analyzed using a suite of MR techniques to discern causal effects.

Results

SUBMITTER: Li J 

PROVIDER: S-EPMC10995375 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature