An entropy-based approach for assessing the directional persistence of cell migration.

ABSTRACT: Cell migration, which is primarily characterized by directional persistence, is essential for the development of normal tissues and organs, as well as for numerous pathological processes. However, there is a lack of simple and efficient tools to analyze the systematic properties of persistence based on cellular trajectory data. Here, we present a novel approach, the entropy of angular distribution , which combines cellular turning dynamics and Shannon entropy to explore the statistical and time-varying properties of persistence that strongly correlate with cellular migration modes. Our results reveal the changes in the persistence of multiple cell lines that are tightly regulated by both intra- and extracellular cues, including Arpin protein, collagen gel/substrate, and physical constraint

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10995411 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature