Nucleosome spacing controls chromatin spatial structure and accessibility.

ABSTRACT: Recent research highlights the significance of the three-dimensional structure of chromatin in regulating various cellular processes, particularly transcription. This is achieved through dynamic chromatin structures that facilitate long-range contacts and control spatial accessibility. Chromatin consists of DNA and a variety of proteins, of which histones play an essential structural role by forming nucleosomes. Extensive experimental and theoretical research in recent decades has yielded conflicting results about key factors that regulate the spatial structure of chromatin, which remains enigmatic. By using a computer model that allows us to simulate chromatin volumes containing physiological nucleosome concentrations, we investigated whether nucleosome spacing or nucleosome density is fu

SUBMITTER: Zulske T 

PROVIDER: S-EPMC10995425 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature