Mechanical control of cell proliferation patterns in growing epithelial monolayers.

ABSTRACT: Cell proliferation plays a crucial role in regulating tissue homeostasis and development. However, our understanding of how cell proliferation is controlled in densely packed tissues is limited. Here we develop a computational framework to predict the patterns of cell proliferation in growing epithelial tissues, connecting single-cell behaviors and cell-cell interactions to tissue-level growth. Our model incorporates probabilistic rules governing cell growth, division, and elimination, also taking into account their feedback with tissue mechanics. In particular, cell growth is suppressed and apoptosis is enhanced in regions of high cell density. With these rules and model parameters calibrated using experimental data for epithelial monolayers, we predict how tissue confinement influences c

SUBMITTER: Carpenter LC 

PROVIDER: S-EPMC10995431 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature