Involvement of BCR::ABL1 in laminin adhesion of Philadelphia chromosome-positive  acute lymphoblastic leukemia through upregulation of integrin α6.

ABSTRACT:

Background

Adhesion of cancer cells to extracellular matrix laminin through the integrin superfamily reportedly induces drug resistance. Heterodimers of integrin α6 (CD49f) with integrin β1 (CD29) or β4 (CD104) are major functional receptors for laminin. Higher CD49f expression is reportedly associated with a poorer response to induction therapy in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Moreover, a xenograft mouse model transplanted with primary BCP-ALL cells revealed that neutralized antibody against CD49f improved survival after chemotherapy.

Aims

Considering the poor outcomes in Philadelphia chromosome (Ph)-positive ALL treated with conventional chemotherapy without tyrosine kinase inhibitors, we sought to investigate an involvement of the lami

SUBMITTER: Takahashi K 

PROVIDER: S-EPMC10995707 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature