Dollo Parsimony Overestimates Ancestral Gene Content Reconstructions.

ABSTRACT: Ancestral reconstruction is a widely used technique that has been applied to understand the evolutionary history of gain and loss of gene families. Ancestral gene content can be reconstructed via different phylogenetic methods, but many current and previous studies employ Dollo parsimony. We hypothesize that Dollo parsimony is not appropriate for ancestral gene content reconstruction inferences based on sequence homology, as Dollo parsimony is derived from the assumption that a complex character cannot be regained. This premise does not accurately model molecular sequence evolution, in which false orthology can result from sequence convergence or lateral gene transfer. The aim of this study is to test Dollo parsimony's suitability for ancestral gene content reconstruction and to compare it

SUBMITTER: Galvez-Morante A 

PROVIDER: S-EPMC10995720 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature