Morphological diversity of cancer cells predicts prognosis across tumor types.

ABSTRACT:

Background

Intratumor heterogeneity drives disease progression and treatment resistance, which can lead to poor patient outcomes. Here, we present a computational approach for quantification of cancer cell diversity in routine hematoxylin-eosin-stained histopathology images.

Methods

We analyzed publicly available digitized whole-slide hematoxylin-eosin images for 2000 patients. Four tumor types were included: lung, head and neck, colon, and rectal cancers, representing major histology subtypes (adenocarcinomas and squamous cell carcinomas). We performed single-cell analysis on hematoxylin-eosin images and trained a deep convolutional autoencoder to automatically learn feature representations of individual cancer nuclei. We then computed features of intranuclear variability a

SUBMITTER: Sali R 

PROVIDER: S-EPMC10995848 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature