Physical activity and checkpoint inhibition: association with toxicity and survival.

ABSTRACT:

Background

Although animal experiments suggest beneficial effects of physical activity (PA) on antitumor immunity, little is known about the effects of PA on immune checkpoint inhibitor (ICI) toxicity and effectiveness in humans. We assessed the association of PA with immune-related adverse events (irAE) and survival in patients undergoing ICI.

Methods

Patients receiving ICI who completed the Dutch short questionnaire to assess health enhancing physical activity (SQUASH) questionnaire at the start of treatment as part of the prospective UNICIT study in an academic hospital were included. PA was quantified by calculating total metabolic equivalent task hours per week (total PA) and hours per week of moderate- to vigorous-intensity PA during sport and leisure time (MVPA-SL). A

SUBMITTER: Verheijden RJ 

PROVIDER: S-EPMC10995850 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature