Association of metformin use and cancer incidence: a systematic review and meta-analysis.

ABSTRACT:

Background

Metformin is among the most widely used antidiabetics medications because of its minimal toxicity, favorable safety profile, availability, and low cost. In addition to its role in diabetes management, metformin may reduce cancer risk.

Methods

We conducted a comprehensive systematic review and meta-analysis to investigate the association between metformin use and cancer risk, with evaluation by specific cancer type when possible. Applicable studies were identified in PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, and Scopus from inception through March 7, 2023, with metformin use categorized as "ever" or "yes" and a cancer diagnosis as the outcome. Article quality was evaluated using National Heart, Lung, and Blood Institute guidelines, and publication b

SUBMITTER: O'Connor L 

PROVIDER: S-EPMC10995851 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature