A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson's disease and dementia with Lewy bodies.

ABSTRACT:

Introduction

Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) show heterogeneous brain atrophy patterns which group-average analyses fail to capture. Neuroanatomical normative modelling overcomes this by comparing individuals to a large reference cohort. Patient-specific atrophy patterns are measured objectively and summarised to index overall neurodegeneration (the 'total outlier count'). We aimed to quantify patterns of neurodegenerative dissimilarity in participants with PD and DLB and evaluate the potential clinical relevance of total outlier count by testing its association with key clinical measures in PD and DLB.

Materials and methods

We included 108 participants with PD and 61 with DLB. PD participants were subclassified into high and low visual performer

SUBMITTER: Bhome R 

PROVIDER: S-EPMC10995913 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature