Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues.

ABSTRACT: The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer's disease. Altered metabolism of essential biometals is another feature of Alzheimer's, with amyloid plaques representing sites of disturbed metal homeostasis. Despite these observations, metal-targeting disease treatments have not been therapeutically effective to date. A better understanding of amyloid plaque composition and the role of the metals associated with them is critical. To establish this knowledge, the ability to resolve chemical variations at nanometer length scales relevant to biology is essential. Here, we present a methodology for the label-free, nanoscale chemical characterization of amyloid plaques within human Alzheimer's disease tissue using synchrotron X-

SUBMITTER: Everett J 

PROVIDER: S-EPMC10995949 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature