Improved clinical outcome prediction in depression using neurodynamics in an emotional face-matching functional MRI task.

ABSTRACT:

Introduction

Approximately one in six people will experience an episode of major depressive disorder (MDD) in their lifetime. Effective treatment is hindered by subjective clinical decision-making and a lack of objective prognostic biomarkers. Functional MRI (fMRI) could provide such an objective measure but the majority of MDD studies has focused on static approaches, disregarding the rapidly changing nature of the brain. In this study, we aim to predict depression severity changes at 3 and 6 months using dynamic fMRI features.

Methods

For our research, we acquired a longitudinal dataset of 32 MDD patients with fMRI scans acquired at baseline and clinical follow-ups 3 and 6 months later. Several measures were derived from an emotion face-matching fMRI dataset: activity in b

SUBMITTER: Pilmeyer J 

PROVIDER: S-EPMC10996064 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature