Smart osteoclasts targeted nanomedicine based on amorphous CaCO₃ for effective osteoporosis reversal.

ABSTRACT:

Background

Osteoporosis is characterized by an imbalance in bone homeostasis, resulting in the excessive dissolution of bone minerals due to the acidified microenvironment mediated by overactive osteoclasts. Oroxylin A (ORO), a natural flavonoid, has shown potential in reversing osteoporosis by inhibiting osteoclast-mediated bone resorption. The limited water solubility and lack of targeting specificity hinder the effective accumulation of Oroxylin A within the pathological environment of osteoporosis.

Results

Osteoclasts' microenvironment-responsive nanoparticles are prepared by incorporating Oroxylin A with amorphous calcium carbonate (ACC) and coated with glutamic acid hexapeptide-modified phospholipids, aiming at reinforcing the drug delivery efficiency as well as therap

SUBMITTER: Yu B 

PROVIDER: S-EPMC10996086 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature