Serum albumin and cardiovascular disease: a Mendelian randomization study.

ABSTRACT:

Background

An increasing body of evidence suggests that serum albumin levels play a role in cardiovascular diseases. However, the specific causal relationship between serum albumin levels and cardiovascular disease remains partially unknown.

Methods

Mendelian randomization (MR) was employed in this study to examine potential causal relationships between instrumental variables and cardiovascular diseases. Specifically, we utilized genetic variants of serum albumin levels within the reference range as our instrumental variables. To acquire data on genetic associations with cardiovascular diseases, we sourced information from renowned genome-wide association studies such as UK BioBank, EMBL-EBI, and FinnGen. Notably, our study leveraged summary statistics from large cohorts tha

SUBMITTER: Huang T 

PROVIDER: S-EPMC10996126 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature