Comorbidities in women with polycystic ovary syndrome: a sibling study.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) has previously been associated with several comorbidities that may have shared genetic, epigenetic, developmental or environmental origins. PCOS may be influenced by prenatal androgen excess, poor intrauterine or childhood environmental factors, childhood obesity and learned health risk behaviors. We analyzed the association between PCOS and several relevant comorbidities while adjusting for early-life biological and socioeconomic conditions, also investigating the extent to which the association is affected by familial risk factors.

Methods

This total-population register-based cohort study included 333,999 full sisters, born between 1962 and 1980. PCOS and comorbidity diagnoses were measured at age 17-45 years through national hos

SUBMITTER: Boldis BV 

PROVIDER: S-EPMC10996169 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature