CGRP-targeted medication in chronic migraine - systematic review.

ABSTRACT:

Background

Chronic migraine is a highly debilitating condition that is often difficult to manage, particularly in the presence of medication overuse headache. Drugs targeting the calcitonin gene-related peptide (CGRP), or its receptor have shown promising results in treating this disorder.

Methods

We searched Pubmed and Embase to identify randomized clinical trials and real-world studies reporting on the use of medication targeting the calcitonin gene-related peptide in patients with chronic migraine.

Results

A total of 270 records were identified. Nineteen studies qualified for the qualitative analysis. Most studies reported on monoclonal antibodies targeting CGRP (anti-CGRP mAbs), that overall prove to be effective in decreasing monthly migraine days by half in abou

SUBMITTER: Oliveira R 

PROVIDER: S-EPMC10996229 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature