Antibiotic use in infants at risk of early-onset sepsis: results from a unicentric retrospective cohort study.

ABSTRACT:

Background

Antibiotic use for early-onset sepsis represents a high percentage of antibiotic consumption in the neonatal setting. Measures to assess infants at risk of early-onset sepsis are needed to optimize antibiotic use. Our primary objective was to assess the impact of a departmental guideline on antibiotic use among term infants with suspected EOS not confirmed, in our neonatal unit.

Methods

Retrospective cohort study, to compare antibiotic use in term infants during a baseline period of January to December 2018, and a postintervention period from October 2019, to September 2020, respectively. The primary outcome was antibiotic use measured by days of therapy, the antibiotic spectrum index, the antibiotic use rate, and the length of therapy.

Results

We included

SUBMITTER: Morales-Betancourt C 

PROVIDER: S-EPMC10996240 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature