The vasculogenic mimicry related signature predicts the prognosis and immunotherapy response in renal clear cell carcinoma.

ABSTRACT:

Background

Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvironment and the influx of tumor-infiltrating lymphocytes, and the combination of its inducers and immune checkpoint inhibitors plays a synergistic role in enhancing antitumor effects.

Methods

We downloaded the data from renal clear cell carcinoma samples and vasculogenic mimicry-related genes to establish a new vasculogenic mimicry-related index (VMRI) using a machine learning approach. Based on VMRI, patients with renal clear cell carcinoma were divided into high VMRI and low VMRI groups, and patients' prognosis, clinical features, tumor immune microenvironm

SUBMITTER: Gu Y 

PROVIDER: S-EPMC10996246 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature