Intestinal cell diversity and treatment responses in a parasitic nematode at single cell resolution.

ABSTRACT:

Background

Parasitic nematodes, significant pathogens for humans, animals, and plants, depend on diverse organ systems for intra-host survival. Understanding the cellular diversity and molecular variations underlying these functions holds promise for developing novel therapeutics, with specific emphasis on the neuromuscular system's functional diversity. The nematode intestine, crucial for anthelmintic therapies, exhibits diverse cellular phenotypes, and unraveling this diversity at the single-cell level is essential for advancing knowledge in anthelmintic research across various organ systems.

Results

Here, using novel single-cell transcriptomics datasets, we delineate cellular diversity within the intestine of adult female Ascaris suum, a parasitic nematode species that in

SUBMITTER: Tyagi R 

PROVIDER: S-EPMC10996262 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature