Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder.

ABSTRACT:

Background

This meta-analysis aimed to explore the most robust findings across numerous existing resting-state functional imaging and voxel-based morphometry (VBM) studies on the functional and structural brain alterations in individuals with autism spectrum disorder (ASD).

Methods

A whole-brain voxel-wise meta-analysis was conducted to compare the differences in the intrinsic functional activity and gray matter volume (GMV) between individuals with ASD and typically developing individuals (TDs) using Seed-based d Mapping software.

Results

A total of 23 functional imaging studies (786 ASD, 710 TDs) and 52 VBM studies (1728 ASD, 1747 TDs) were included. Compared with TDs, individuals with ASD displayed resting-state functional decreases in the left insula (extending to

SUBMITTER: Guo Z 

PROVIDER: S-EPMC10996269 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature