Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage.

ABSTRACT:

Background

Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 channels in astrocytes from adolescent rats. However, whether ethanol directly affects astroglial hemichannels and, if so, how this impacts the function and survival of astrocytes remains to be elucidated.

Results

Clinically relevant concentrations of ethanol boost the opening of Cx43 hemichannels and Panx1 channels in mouse cortical astrocytes, resulting in the release of ATP and glutamate. The activation of these large-pore channels is dependent on Toll-like receptor 4,

SUBMITTER: Gomez GI 

PROVIDER: S-EPMC10996276 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature