Construction and experimental validation of a novel ferroptosis-related gene signature for myelodysplastic syndromes.

ABSTRACT:

Background

Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by morphological abnormalities and peripheral blood cytopenias, carrying a risk of progression to acute myeloid leukemia. Although ferroptosis is a promising target for MDS treatment, the specific roles of ferroptosis-related genes (FRGs) in MDS diagnosis have not been elucidated.

Methods

MDS-related microarray data were obtained from the Gene Expression Omnibus database. A comprehensive analysis of FRG expression levels in patients with MDS and controls was conducted, followed by the use of multiple machine learning methods to establish prediction models. The predictive ability of the optimal model was evaluated using nomogram analysis and an external data set. Functional analysis wa

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10996383 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature