A reproducible dynamic phantom for sequence testing in hyperpolarised ¹³C-magnetic resonance.

ABSTRACT:

Objective

To develop a phantom system which can be integrated with an automated injection system, eliminating the experimental variability that arises with manual injection; for the purposes of pulse sequence testing and metric derivation in hyperpolarised ¹³C-MR.

Methods

The custom dynamic phantom was machined from Ultem and filled with a nicotinamide adenine dinucleotide and lactate dehydrogenase mixture dissolved in phosphate buffered saline. Hyperpolarised [1-¹³C]-pyruvate was then injected into the phantom (n = 8) via an automated syringe pump and the conversion of pyruvate to lactate monitored through a ¹³C imaging sequence.

Results

The phantom showed low coefficient of variation for the lactate to pyruvate peak signal hei

SUBMITTER: Chowdhury R 

PROVIDER: S-EPMC10996405 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature