Effects of Micromachining on Anti-oxidant Elution from a Mechanically-Adaptive Polymer.

ABSTRACT: Intracortical microelectrodes (IMEs) can be used to restore motor and sensory function as a part of brain-computer interfaces in individuals with neuromusculoskeletal disorders. However, the neuroinflammatory response to IMEs can result in their premature failure, leading to reduced therapeutic efficacy. Mechanically-adaptive, resveratrol-eluting (MARE) neural probes target two mechanisms believed to contribute to the neuroinflammatory response by reducing the mechanical mismatch between the brain tissue and device, as well as locally delivering an antioxidant therapeutic. To create the mechanically-adaptive substrate, a dispersion, casting, and evaporation method is used, followed by a microfabrication process to integrate functional recording electrodes on the material. Resveratrol relea

SUBMITTER: Mueller NN 

PROVIDER: S-EPMC10996452 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature