Synaptic weight dynamics underlying systems consolidation of a memory.

ABSTRACT: Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures modeling core features of many memory systems: an early- and late-learning brain region and two sites of plasticity. We show that the synaptic dynamics of the circuit during consolidation of an analog memory can be understood as a temporal integration process, by which transient changes in activity driven by plasticity in the early-learning area are accumulated into persistent synaptic changes at the late-learning site. This simple principle leads to two constraints on the circuit operation for consolidation to be implemented s

SUBMITTER: Bhasin BJ 

PROVIDER: S-EPMC10996481 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature