Ontology highlight
ABSTRACT:
SUBMITTER: Powell BM
PROVIDER: S-EPMC10996489 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Powell Barrett M BM Brant Tyler S TS Davis Joseph H JH Mosalaganti Shyamal S
bioRxiv : the preprint server for biology 20240326
Rapid structural analysis of purified proteins and their complexes has become increasingly common thanks to key methodological advances in cryo-electron microscopy (cryo-EM) and associated data processing software packages. In contrast, analogous structural analysis in cells via cryo-electron tomography (cryo-ET) remains challenging due to critical technical bottlenecks, including low-throughput sample preparation and imaging, and laborious data processing methods. Here, we describe the developm ...[more]