Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted.

ABSTRACT: Tissue-resident memory CD8 T cells (T_RM) kill infected cells and recruit additional immune cells to limit pathogen invasion at barrier sites. Small intestinal (SI) T_RM cells consist of distinct subpopulations with higher expression of effector molecules or greater memory potential. We hypothesized that occupancy of diverse anatomical niches imprints these distinct T_RM transcriptional programs. We leveraged human samples and a murine model of acute systemic viral infection to profile the location and transcriptome of pathogen-specific T_RM cell differentiation at single-transcript resolution. We developed computational approaches to capture cellular locations along three anatomical axes of the small intestine and to visualize the spatiotemporal dis

SUBMITTER: Reina-Campos M 

PROVIDER: S-EPMC10996520 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature