LeGenD: determining N-glycoprofiles using an explainable AI-leveraged model with lectin profiling.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC10996628 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
LeGenD: determining N-glycoprofiles using an explainable AI-leveraged model with lectin profiling.
Li Haining H Peralta Angelo G AG Schoffelen Sanne S Hansen Anders Holmgaard AH Arnsdorf Johnny J Schinn Song-Min SM Skidmore Jonathan J Choudhury Biswa B Paulchakrabarti Mousumi M Voldborg Bjorn G BG Chiang Austin W T AWT Lewis Nathan E NE
bioRxiv : the preprint server for biology 20240330
Glycosylation affects many vital functions of organisms. Therefore, its surveillance is critical from basic science to biotechnology, including biopharmaceutical development and clinical diagnostics. However, conventional glycan structure analysis faces challenges with throughput and cost. Lectins offer an alternative approach for analyzing glycans, but they only provide glycan epitopes and not full glycan structure information. To overcome these limitations, we developed LeGenD, a lectin and AI ...[more]
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